Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase

The integration of the retroviral genome into the chromatin of the infected cell is catalysed by the integrase (IN)•viral DNA complex (intasome). This process requires functional association between the integration complex and the nucleosomes. Direct intasome/histone contacts have been reported to m...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Mauro, Eric, Lesbats, Paul, Lapaillerie, Delphine, Chaignepain, Stephane, Maillot, Benoit, Oladosu, Oyindamola, Robert, Xavier, Fiorini, Francesca, Kieffer, Bruno, Bouaziz, Serge, Gouet, Patrice, Ruff, Marc, Parissi, Vincent
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Nucleic Acid Enzymes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468294/
https://ncbi.nlm.nih.gov/pubmed/30767014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz091
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