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A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension

BACKGROUND AND PURPOSE: Apelin is an endogenous vasodilatory and inotropic peptide that is down‐regulated in human pulmonary arterial hypertension, although the density of the apelin receptor is not significantly attenuated. We hypothesised that a G protein‐biased apelin analogue MM07, which is more...

詳細記述

保存先:
書誌詳細
出版年:Br J Pharmacol
主要な著者: Yang, Peiran, Read, Cai, Kuc, Rhoda E., Nyimanu, Duuamene, Williams, Thomas L., Crosby, Alexi, Buonincontri, Guido, Southwood, Mark, Sawiak, Stephen J., Glen, Robert C., Morrell, Nicholas W., Davenport, Anthony P., Maguire, Janet J.
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468262/
https://ncbi.nlm.nih.gov/pubmed/30710493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14603
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