The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo

Signaling through the apelin receptor is beneficial for a number of diseases including pulmonary arterial hypertension. The endogenous small peptides, apelin and elabela/toddler, are downregulated in pulmonary arterial hypertension but are not suitable for exogenous administration owing to a lack of...

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Publicat a:Front Pharmacol
Autors principals: Read, Cai, Nyimanu, Duuamene, Yang, Peiran, Kuc, Rhoda E., Williams, Thomas L., Fitzpatrick, Christopher M., Foster, Richard, Glen, Robert C., Maguire, Janet J., Davenport, Anthony P.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7944139/
https://ncbi.nlm.nih.gov/pubmed/33716722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.588669
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