The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo

Signaling through the apelin receptor is beneficial for a number of diseases including pulmonary arterial hypertension. The endogenous small peptides, apelin and elabela/toddler, are downregulated in pulmonary arterial hypertension but are not suitable for exogenous administration owing to a lack of...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Read, Cai, Nyimanu, Duuamene, Yang, Peiran, Kuc, Rhoda E., Williams, Thomas L., Fitzpatrick, Christopher M., Foster, Richard, Glen, Robert C., Maguire, Janet J., Davenport, Anthony P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7944139/
https://ncbi.nlm.nih.gov/pubmed/33716722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.588669
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi