Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension

BACKGROUND: Elabela/toddler (ELA) is a critical cardiac developmental peptide that acts through the G-protein–coupled apelin receptor, despite lack of sequence similarity to the established ligand apelin. Our aim was to investigate the receptor pharmacology, expression pattern, and in vivo function...

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Publicat a:Circulation
Autors principals: Yang, Peiran, Read, Cai, Kuc, Rhoda E., Buonincontri, Guido, Southwood, Mark, Torella, Rubben, Upton, Paul D., Crosby, Alexi, Sawiak, Stephen J., Carpenter, T. Adrian, Glen, Robert C., Morrell, Nicholas W., Maguire, Janet J., Davenport, Anthony P.
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2017
Matèries:
Original Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363837/
https://ncbi.nlm.nih.gov/pubmed/28137936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.023218
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