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The ATP-bound conformation of the Mre11–Rad50 complex is essential for Tel1/ATM activation
Activation of the checkpoint protein Tel1 requires the Mre11–Rad50–Xrs2 (MRX) complex, which recruits Tel1 at DNA double-strand breaks (DSBs) through direct interaction between Tel1 and Xrs2. However, in vitro Tel1 activation by MRX requires ATP binding to Rad50, suggesting a role also for the MR su...
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| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6468247/ https://ncbi.nlm.nih.gov/pubmed/30698745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz038 |
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