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An innate interaction between IL-18 and the propeptide that inactivates its precursor form
Uncontrolled secretion of mature interleukin (IL)-1β and IL-18 is responsible for severe autoinflammatory or autoimmune disorders and various allergic diseases. Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6467916/ https://ncbi.nlm.nih.gov/pubmed/30992532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42661-5 |
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