Llwytho...
Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase
Gaucher’s disease is a lysosomal disease caused by mutations in the β-glucocerebrosidase gene (GBA1, GCase) that have been also linked to increased risk of Parkinson’s disease and Diffuse Lewy Body Dementia. Prior studies have suggested that mutant GCase protein undergoes misfolding and degradation...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Med Chem |
|---|---|
| Prif Awduron: | , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2019
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6467782/ https://ncbi.nlm.nih.gov/pubmed/30645117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01294 |
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