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Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase
Gaucher’s disease is a lysosomal disease caused by mutations in the β-glucocerebrosidase gene (GBA1, GCase) that have been also linked to increased risk of Parkinson’s disease and Diffuse Lewy Body Dementia. Prior studies have suggested that mutant GCase protein undergoes misfolding and degradation...
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| Publicado no: | J Med Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6467782/ https://ncbi.nlm.nih.gov/pubmed/30645117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01294 |
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