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Direct Catalytic Asymmetric Synthesis of trifluoromethylated γ-Amino Esters/Lactones via Umpolung Strategy

Enabled by the discovery of new cinchinium salts and co-additives, a direct and efficient asymmetric access to trifluoromethylated γ-amino esters/lactones has been realized through the enantioselective and diastereoselective umpolung reaction of trifluoromethyl imines with acrylates or α,β-unsaturat...

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Dettagli Bibliografici
Pubblicato in:J Org Chem
Autori principali: Hu, Bin, Deng, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467775/
https://ncbi.nlm.nih.gov/pubmed/30543752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.8b02893
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