Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure/Activity Analysis.

Dietary flavonoids inhibit certain protein- and phospholipid-kinases, by competing for their ATP-binding sites. These nucleotide pockets have structural elements that are well-conserved in two human small-molecule kinases, inositol hexakisphosphate kinase (IP6K) and inositol polyphosphate multikinas...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Gu, Chunfang, Stashko, Michael A., Puhl-Rubio, Ana C., Chakraborty, Molee, Chakraborty, Anutosh, Frye, Stephen V., Pearce, Kenneth H., Wang, Xiaodong, Shears, Stephen B., Wang, Huanchen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467728/
https://ncbi.nlm.nih.gov/pubmed/30624931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01593
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