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Synthesis and in vitro characterization of trehalose-based inhibitors of mycobacterial trehalose 6-phosphate phosphatases

α,α’-Trehalose plays roles in the synthesis of several cell wall components involved in pathogenic mycobacteria virulence. Its absence in mammalian biochemistry makes trehalose-related biochemical processes potential targets for chemotherapy. The trehalose-6-phosphate synthase (TPS)/trehalose-6-phos...

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Udgivet i:Chembiochem
Main Authors: Kapil, Sunayana, Petit, Cecile, Drago, Victoria N., Ronning, Donald R., Sucheck, Steven J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467533/
https://ncbi.nlm.nih.gov/pubmed/30402996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800551
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