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Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

BACKGROUND: A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to develop a proteomic biomarker of risk of TB progression for ultimate translation...

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Veröffentlicht in:PLoS Med
Hauptverfasser: Penn-Nicholson, Adam, Hraha, Thomas, Thompson, Ethan G., Sterling, David, Mbandi, Stanley Kimbung, Wall, Kirsten M., Fisher, Michelle, Suliman, Sara, Shankar, Smitha, Hanekom, Willem A., Janjic, Nebojsa, Hatherill, Mark, Kaufmann, Stefan H. E., Sutherland, Jayne, Walzl, Gerhard, De Groote, Mary Ann, Ochsner, Urs, Zak, Daniel E., Scriba, Thomas J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467365/
https://ncbi.nlm.nih.gov/pubmed/30990820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002781
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