Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies

[Image: see text] The key role of RNA-binding proteins (RBPs) in regulating post-transcriptional processes and their involvement in several pathologies (i.e., cancer and neurodegeneration) have highlighted their potential as therapeutic targets. In this scenario, Embryonic Lethal Abnormal Vision (EL...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:ACS Med Chem Lett
المؤلفون الرئيسيون: Della Volpe, Serena, Nasti, Rita, Queirolo, Michele, Unver, M. Yagiz, Jumde, Varsha K., Dömling, Alexander, Vasile, Francesca, Potenza, Donatella, Ambrosio, Francesca Alessandra, Costa, Giosué, Alcaro, Stefano, Zucal, Chiara, Provenzani, Alessandro, Di Giacomo, Marcello, Rossi, Daniela, Hirsch, Anna K. H., Collina, Simona
التنسيق: Artigo
اللغة:Inglês
منشور في: American Chemical Society 2019
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466816/
https://ncbi.nlm.nih.gov/pubmed/30996806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00600
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