Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies

[Image: see text] The key role of RNA-binding proteins (RBPs) in regulating post-transcriptional processes and their involvement in several pathologies (i.e., cancer and neurodegeneration) have highlighted their potential as therapeutic targets. In this scenario, Embryonic Lethal Abnormal Vision (EL...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Della Volpe, Serena, Nasti, Rita, Queirolo, Michele, Unver, M. Yagiz, Jumde, Varsha K., Dömling, Alexander, Vasile, Francesca, Potenza, Donatella, Ambrosio, Francesca Alessandra, Costa, Giosué, Alcaro, Stefano, Zucal, Chiara, Provenzani, Alessandro, Di Giacomo, Marcello, Rossi, Daniela, Hirsch, Anna K. H., Collina, Simona
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466816/
https://ncbi.nlm.nih.gov/pubmed/30996806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00600
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