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Dimer formation drives the activation of the cell death protease caspase 9

A critical step in the induction of apoptosis is the activation of the apoptotic initiator caspase 9. We show that at its normal physiological concentration, caspase 9 is primarily an inactive monomer (zymogen), and that activity is associated with a dimeric species. At the high concentrations used...

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Autori principali: Renatus, Martin, Stennicke, Henning R., Scott, Fiona L., Liddington, Robert C., Salvesen, Guy S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC64668/
https://ncbi.nlm.nih.gov/pubmed/11734640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231465798
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