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Dimer formation drives the activation of the cell death protease caspase 9
A critical step in the induction of apoptosis is the activation of the apoptotic initiator caspase 9. We show that at its normal physiological concentration, caspase 9 is primarily an inactive monomer (zymogen), and that activity is associated with a dimeric species. At the high concentrations used...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC64668/ https://ncbi.nlm.nih.gov/pubmed/11734640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231465798 |
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