Inhibitor specificity of recombinant and endogenous caspase-9.

Apoptosis triggered through the intrinsic pathway by radiation and anti-neoplastic drugs is initiated by the activation of caspase-9. To elucidate control mechanisms in this pathway we used a range of synthetic and natural reagents. The inhibitory potency of acetyl-Asp-Glu-Val-Asp-aldehyde ('Ac...

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Bibliografiske detaljer
Main Authors: Ryan, Ciara A, Stennicke, Henning R, Nava, Victor E, Burch, Jennifer B, Hardwick, J Marie, Salvesen, Guy S
Format: Artigo
Sprog:Inglês
Udgivet: 2002
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222808/
https://ncbi.nlm.nih.gov/pubmed/12067274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020863
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