MPT0G413, A Novel HDAC6-Selective Inhibitor, and Bortezomib Synergistically Exert Anti-tumor Activity in Multiple Myeloma Cells

In multiple myeloma (MM), homeostasis is largely maintained by misfolded protein clearance via the proteasomal and aggresomal pathways. Histone deacetylase 6 (HDAC6) binds polyubiquitinated proteins and dynein motors and transports this protein cargo to the aggresome for further degradation. Accordi...

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Publicat a:Front Oncol
Autors principals: Huang, Fang-I, Wu, Yi-Wen, Sung, Ting-Yi, Liou, Jing-Ping, Lin, Mei-Hsiang, Pan, Shiow-Lin, Yang, Chia-Ron
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465934/
https://ncbi.nlm.nih.gov/pubmed/31024851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00249
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