A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin

Accumulation of genetic and epigenetic changes contributes to cancer development and progression. Compared with gene mutations or deletions, epigenetic changes are reversible, which alter the chromatin structure remodeling instead of changes in DNA sequence, and therefore become a promising strategy...

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Detalles Bibliográficos
Main Authors: Wang, Li-Ting, Liou, Jing-Ping, Li, Yu-Hsuan, Liu, Yi-Min, Pan, Shiow-Lin, Teng, Che-Ming
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2014
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170623/
https://ncbi.nlm.nih.gov/pubmed/25015091
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