Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

RIPK1 regulates cell death and inflammation through kinase-dependent and -independent mechanisms. As a scaffold, RIPK1 inhibits caspase-8-dependent apoptosis and RIPK3/MLKL-dependent necroptosis. As a kinase, RIPK1 paradoxically induces these cell death modalities. The molecular switch between RIPK1...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Dondelinger, Yves, Delanghe, Tom, Priem, Dario, Wynosky-Dolfi, Meghan A., Sorobetea, Daniel, Rojas-Rivera, Diego, Giansanti, Piero, Roelandt, Ria, Gropengiesser, Julia, Ruckdeschel, Klaus, Savvides, Savvas N., Heck, Albert J. R., Vandenabeele, Peter, Brodsky, Igor E., Bertrand, Mathieu J. M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465317/
https://ncbi.nlm.nih.gov/pubmed/30988283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09690-0
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars