Intermediate Domain of Receptor-interacting Protein Kinase 1 (RIPK1) Determines Switch between Necroptosis and RIPK1 Kinase-dependent Apoptosis

Receptor-interacting protein kinase 1 (RIPK1) is an important component of the tumor necrosis factor receptor 1 (TNFR1) signaling pathway. Depending on the cell type and conditions, RIPK1 mediates MAPK and NF-κB activation as well as cell death. Using a mutant form of RIPK1 (RIPK1ΔID) lacking the in...

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Bibliografische gegevens
Hoofdauteurs: Duprez, Linde, Bertrand, Mathieu J. M., Vanden Berghe, Tom, Dondelinger, Yves, Festjens, Nele, Vandenabeele, Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2012
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340215/
https://ncbi.nlm.nih.gov/pubmed/22362767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.288670
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