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Repeat domain-associated O-glycans govern PMEL fibrillar sheet architecture
PMEL is a pigment cell-specific protein that forms a functional amyloid matrix in melanosomes. The matrix consists of well-separated fibrillar sheets on which the pigment melanin is deposited. Using electron tomography, we demonstrate that this sheet architecture is governed by the PMEL repeat (RPT)...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6465243/ https://ncbi.nlm.nih.gov/pubmed/30988362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42571-6 |
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