Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships

“Thorough QT/QTc” (TQT) studies are cornerstones of clinical cardiovascular safety assessment. However, TQT studies are resource intensive, and preclinical models predictive of the threshold of regulatory concern are lacking. We hypothesized that an in vitro model using iPSC-derived cardiomyocytes f...

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Detaylı Bibliyografya
Yayımlandı:Clin Pharmacol Ther
Asıl Yazarlar: Blanchette, Alexander D., Grimm, Fabian A., Dalaijamts, Chimedullam, Hsieh, Nan-Hung, Ferguson, Kyle, Luo, Yu-Syuan, Rusyn, Ivan, Chiu, Weihsueh A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465173/
https://ncbi.nlm.nih.gov/pubmed/30346629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1259
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