Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships

“Thorough QT/QTc” (TQT) studies are cornerstones of clinical cardiovascular safety assessment. However, TQT studies are resource intensive, and preclinical models predictive of the threshold of regulatory concern are lacking. We hypothesized that an in vitro model using iPSC-derived cardiomyocytes f...

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Vydáno v:Clin Pharmacol Ther
Hlavní autoři: Blanchette, Alexander D., Grimm, Fabian A., Dalaijamts, Chimedullam, Hsieh, Nan-Hung, Ferguson, Kyle, Luo, Yu-Syuan, Rusyn, Ivan, Chiu, Weihsueh A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465173/
https://ncbi.nlm.nih.gov/pubmed/30346629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1259
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