Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships

“Thorough QT/QTc” (TQT) studies are cornerstones of clinical cardiovascular safety assessment. However, TQT studies are resource intensive, and preclinical models predictive of the threshold of regulatory concern are lacking. We hypothesized that an in vitro model using iPSC-derived cardiomyocytes f...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clin Pharmacol Ther
Hauptverfasser: Blanchette, Alexander D., Grimm, Fabian A., Dalaijamts, Chimedullam, Hsieh, Nan-Hung, Ferguson, Kyle, Luo, Yu-Syuan, Rusyn, Ivan, Chiu, Weihsueh A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465173/
https://ncbi.nlm.nih.gov/pubmed/30346629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1259
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge