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Toxicokinetics of Chiral PCB 136 and its Hydroxylated Metabolites in Mice with a Liver-Specific Deletion of Cytochrome P450 Reductase

Exposure to polychlorinated biphenyls (PCBs) has been implicated in adverse human health effects, including developmental neurotoxicity. Several neurotoxic PCBs are chiral and undergo atropisomeric enrichment in vivo due to atropselective metabolism by cytochrome P450 enzymes. Here we study how the...

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Bibliografiske detaljer
Udgivet i:Chem Res Toxicol
Main Authors: Li, Xueshu, Wu, Xianai, Kelly, Kevin M., Veng-Pedersen, Peter, Lehmler, Hans-Joachim
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465157/
https://ncbi.nlm.nih.gov/pubmed/30729780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.8b00389
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