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Genotype-phenotype relations of the von Hippel-Lindau tumor suppressor inferred from a large-scale analysis of disease mutations and interactors

Familiar cancers represent a privileged point of view for studying the complex cellular events inducing tumor transformation. Von Hippel-Lindau syndrome, a familiar predisposition to develop cancer is a clear example. Here, we present our efforts to decipher the role of von Hippel-Lindau tumor suppr...

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Publicado en:PLoS Comput Biol
Autores principales: Minervini, Giovanni, Quaglia, Federica, Tabaro, Francesco, Tosatto, Silvio C. E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6464237/
https://ncbi.nlm.nih.gov/pubmed/30943211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006478
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