Insulin/IGF1 signalling mediates the effects of β(2)‐adrenergic agonist on muscle proteostasis and growth

BACKGROUND: Stimulation of β(2)‐adrenoceptors can promote muscle hypertrophy and fibre type shift, and it can counteract atrophy and weakness. The underlying mechanisms remain elusive. METHODS: Fed wild type (WT), 2‐day fasted WT, muscle‐specific insulin (INS) receptor (IR) knockout (M‐IR(−/−)), and...

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Pubblicato in:J Cachexia Sarcopenia Muscle
Autori principali: Gonçalves, Dawit A., Silveira, Wilian A., Manfredi, Leandro H., Graça, Flávia A., Armani, Andrea, Bertaggia, Enrico, O´Neill, Brian T., Lautherbach, Natalia, Machado, Juliano, Nogara, Leonardo, Pereira, Marcelo G., Arcidiacono, Diletta, Realdon, Stefano, Kahn, C. Ronald, Sandri, Marco, Kettelhut, Isis C., Navegantes, Luiz Carlos C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463755/
https://ncbi.nlm.nih.gov/pubmed/30932373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12395
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