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Influence of the familial Alzheimer's disease–associated T43I mutation on the transmembrane structure and γ-secretase processing of the C99 peptide
Extracellular deposition of β-amyloid (Aβ) peptides in the brain is a hallmark of Alzheimer's disease (AD). Upon β-secretase–mediated cleavage of the β C-terminal fragment (β-CTF) from the Aβ precursor protein, the γ-secretase complex produces the Aβ peptides associated with AD. The familial T4...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6463720/ https://ncbi.nlm.nih.gov/pubmed/30755484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006061 |
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