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Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation

Hepatitis C virus (HCV) establishes a chronic infection that can lead to cirrhosis and hepatocellular carcinoma. The HCV life cycle is closely associated with host factors that promote or restrict viral replication, the characterization of which could help to identify potential therapeutic targets....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kitab, Bouchra, Satoh, Masaaki, Ohmori, Yusuke, Munakata, Tsubasa, Sudoh, Masayuki, Kohara, Michinori, Tsukiyama-Kohara, Kyoko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463693/
https://ncbi.nlm.nih.gov/pubmed/30755480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004397
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