Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation

Hepatitis C virus (HCV) establishes a chronic infection that can lead to cirrhosis and hepatocellular carcinoma. The HCV life cycle is closely associated with host factors that promote or restrict viral replication, the characterization of which could help to identify potential therapeutic targets....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Kitab, Bouchra, Satoh, Masaaki, Ohmori, Yusuke, Munakata, Tsubasa, Sudoh, Masayuki, Kohara, Michinori, Tsukiyama-Kohara, Kyoko
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2019
Gaiak:
Microbiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463693/
https://ncbi.nlm.nih.gov/pubmed/30755480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004397
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