Shear stress and platelet‐induced tensile forces regulate ADAMTS13‐localization within the platelet thrombus

BACKGROUND: The multimeric glycoprotein von Willebrand factor (VWF) mediates platelet adhesion and aggregation at the site of vessel injury. The adhesive activity of VWF is influenced by its multimer length which is regulated by the metalloprotease ADAMTS13. The ability of ADAMTS13 to regulate plate...

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Publicat a:Res Pract Thromb Haemost
Autors principals: Shida, Yasuaki, Swystun, Laura L., Brown, Christine, Mewburn, Jeffrey, Nesbitt, Kate, Danisment, Ozge, Riches, Jonathan Jacob, Hough, Christine, Lillicrap, David
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Original Articles: Haemostasis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462754/
https://ncbi.nlm.nih.gov/pubmed/31011709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12196
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