Shear stress and platelet‐induced tensile forces regulate ADAMTS13‐localization within the platelet thrombus

BACKGROUND: The multimeric glycoprotein von Willebrand factor (VWF) mediates platelet adhesion and aggregation at the site of vessel injury. The adhesive activity of VWF is influenced by its multimer length which is regulated by the metalloprotease ADAMTS13. The ability of ADAMTS13 to regulate plate...

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Bibliografiske detaljer
Udgivet i:Res Pract Thromb Haemost
Main Authors: Shida, Yasuaki, Swystun, Laura L., Brown, Christine, Mewburn, Jeffrey, Nesbitt, Kate, Danisment, Ozge, Riches, Jonathan Jacob, Hough, Christine, Lillicrap, David
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Original Articles: Haemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462754/
https://ncbi.nlm.nih.gov/pubmed/31011709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12196
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