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Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation

The initiation phase of HIV reverse transcription has features that are distinct from its elongation phase. The first structure of a reverse transcription initiation complex (RTIC) that trapped the complex after incorporation of one ddCMP nucleotide was published recently [Larsen KP, et al. (2018) N...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Das, Kalyan, Martinez, Sergio E., DeStefano, Jeffrey J., Arnold, Eddy
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462067/
https://ncbi.nlm.nih.gov/pubmed/30902895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814170116
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