HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

The mechanisms by which regulatory T cells (Tregs) migrate to and function within the hypoxic tumor microenvironment are unclear. Our studies indicate that specific ablation of hypoxia-inducible factor 1α (HIF-1α) in Tregs results in enhanced CD8(+) T cell suppression versus wild-type Tregs under hy...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Miska, Jason, Lee-Chang, Catalina, Rashidi, Aida, Muroski, Megan E., Chang, Alan L., Lopez-Rosas, Aurora, Zhang, Peng, Panek, Wojciech K., Cordero, Alex, Han, Yu, Ahmed, Atique U., Chandel, Navdeep S., Lesniak, Maciej S.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461402/
https://ncbi.nlm.nih.gov/pubmed/30943404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.03.029
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