Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma

Glioblastoma is characterized by the robust infiltration of immunosuppressive tumor-associated myeloid cells (TAMCs). It is not fully understood how TAMCs survive in the acidic tumor microenvironment to cause immunosuppression in glioblastoma. Metabolic and RNA-seq analysis of TAMCs revealed that th...

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Sparad:
Bibliografiska uppgifter
I publikationen:Sci Adv
Huvudupphovsmän: Miska, Jason, Rashidi, Aida, Lee-Chang, Catalina, Gao, Peng, Lopez-Rosas, Aurora, Zhang, Peng, Burga, Rachel, Castro, Brandyn, Xiao, Ting, Han, Yu, Hou, David, Sampat, Samay, Cordero, Alex, Stoolman, Joshua S., Horbinski, Craig M., Burns, Mark, Reshetnyak, Yana K., Chandel, Navdeep S., Lesniak, Maciej S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Association for the Advancement of Science 2021
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888943/
https://ncbi.nlm.nih.gov/pubmed/33597238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc8929
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