Myeloid-derived suppressive cells promote B cell–mediated immunosuppression via transfer of PD-L1 in glioblastoma

The potent immunosuppression induced by glioblastoma (GBM) is one of the primary obstacles to finding effective immunotherapies. One hallmark of the GBM-associated immunosuppressive landscape is the massive infiltration of myeloid-derived suppressor cells (MDSCs) and, to a lesser extent, regulatory...

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Publicat a:Cancer Immunol Res
Autors principals: Lee-Chang, Catalina, Rashidi, Aida, Miska, Jason, Zhang, Peng, Pituch, Katarzyna C., Hou, David, Xiao, Ting, Fischietti, Mariafausta, Kang, Seong Jae, Appin, Christina L., Horbinski, Craig, Platanias, Leonidas C., Lopez-Rosas, Aurora, Han, Yu, Balyasnikova, Irina V., Lesniak, Maciej S.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891201/
https://ncbi.nlm.nih.gov/pubmed/31530559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0240
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