Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice

Mice deficient in SHANK-associated RH domain-interacting protein (SHARPIN), a component of the linear ubiquitin chain assembly complex (LUBAC), develop a spontaneous inflammatory disorder with pathologic hallmarks similar to atopic dermatitis and psoriasis in humans. Previous studies identified the...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Sharma, Bhesh Raj, Karki, Rajendra, Lee, Ein, Zhu, Qifan, Gurung, Prajwal, Kanneganti, Thirumala-Devi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460383/
https://ncbi.nlm.nih.gov/pubmed/30038386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0159-7
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