HIF-1 regulation of miR-29c impairs SERCA2 expression and cardiac contractility

The principal regulator of cellular response to low oxygen is hypoxia-inducible factor (HIF)-1, which is stabilized in several forms of heart failure. Our laboratory developed a mouse strain in which a stable form of HIF-1 can be inducibly expressed in cardiomyocytes. Strikingly, these mice show a r...

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Detaylı Bibliyografya
Yayımlandı:Am J Physiol Heart Circ Physiol
Asıl Yazarlar: Williams, Allison Lesher, Walton, Chad B., MacCannell, Keith A., Avelar, Abigail, Shohet, Ralph V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459310/
https://ncbi.nlm.nih.gov/pubmed/30575439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00617.2018
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