Conditional HIF-1α Expression Produces a Reversible Cardiomyopathy

BACKGROUND: The response to hypoxia in tissues is regulated by the heterodimeric transcription factor Hypoxia Inducible Factor-1 (HIF-1). METHODOLOGY/PRINCIPAL FINDINGS: We have created a strain of mice with inducible cardiomyocyte-specific expression of a mutated, oxygen-stable, form of HIF-1α. Car...

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Detalhes bibliográficos
Main Authors: Bekeredjian, Raffi, Walton, Chad B., MacCannell, Keith A., Ecker, Jennifer, Kruse, Fred, Outten, Joel T., Sutcliffe, David, Gerard, Robert D., Bruick, Richard K., Shohet, Ralph V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908132/
https://ncbi.nlm.nih.gov/pubmed/20657781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011693
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