Cardiac angiogenesis directed by stable Hypoxia Inducible Factor-1

BACKGROUND: The heterodimeric, oxygen-sensitive transcription factor Hypoxia Inducible Factor-1 (HIF-1) orchestrates angiogenesis and plays a key role in the response to ischemia and the growth of cancers. METHODS: We developed a transgenic mouse line in which expression of an oxygen-stable HIF-1α c...

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Autori principali: Walton, Chad B, Ecker, Jennifer, Anderson, Cynthia D, Outten, Joel T, Allison, Randall Z, Shohet, Ralph V
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766207/
https://ncbi.nlm.nih.gov/pubmed/23987100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-824X-5-15
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