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HIF-1 regulation of miR-29c impairs SERCA2 expression and cardiac contractility
The principal regulator of cellular response to low oxygen is hypoxia-inducible factor (HIF)-1, which is stabilized in several forms of heart failure. Our laboratory developed a mouse strain in which a stable form of HIF-1 can be inducibly expressed in cardiomyocytes. Strikingly, these mice show a r...
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| Publicado no: | Am J Physiol Heart Circ Physiol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6459310/ https://ncbi.nlm.nih.gov/pubmed/30575439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00617.2018 |
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