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Synthesis and biological activity of 4-amino-3-chloro-1H-pyrrole-2,5-diones

4-Amino-3-chloro-1H-pyrrole-2,5-dione derivatives were designed and synthesized as potential tyrosine kinase inhibitors. One of them has been shown to inhibit growth of cancer cell lines and in vivo tumors. To determine the impact of side groups on biological activity the ability of different 4-amin...

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Dettagli Bibliografici
Pubblicato in:In Silico Pharmacol
Autori principali: Kuznietsova, Halyna M., Hurmach, Vasyl V., Bychko, Andriy V., Tykhoniuk, Olena I., Milokhov, Demyd S., Khilya, Olga V., Volovenko, Yulian M., Rybalchenko, Volodymyr K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458214/
https://ncbi.nlm.nih.gov/pubmed/31032168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40203-019-0051-2
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