Synthesis and biological activity of 4-amino-3-chloro-1H-pyrrole-2,5-diones

4-Amino-3-chloro-1H-pyrrole-2,5-dione derivatives were designed and synthesized as potential tyrosine kinase inhibitors. One of them has been shown to inhibit growth of cancer cell lines and in vivo tumors. To determine the impact of side groups on biological activity the ability of different 4-amin...

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Bibliographic Details
Published in:In Silico Pharmacol
Main Authors: Kuznietsova, Halyna M., Hurmach, Vasyl V., Bychko, Andriy V., Tykhoniuk, Olena I., Milokhov, Demyd S., Khilya, Olga V., Volovenko, Yulian M., Rybalchenko, Volodymyr K.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458214/
https://ncbi.nlm.nih.gov/pubmed/31032168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40203-019-0051-2
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