Synthesis and biological activity of 4-amino-3-chloro-1H-pyrrole-2,5-diones

4-Amino-3-chloro-1H-pyrrole-2,5-dione derivatives were designed and synthesized as potential tyrosine kinase inhibitors. One of them has been shown to inhibit growth of cancer cell lines and in vivo tumors. To determine the impact of side groups on biological activity the ability of different 4-amin...

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Vydáno v:In Silico Pharmacol
Hlavní autoři: Kuznietsova, Halyna M., Hurmach, Vasyl V., Bychko, Andriy V., Tykhoniuk, Olena I., Milokhov, Demyd S., Khilya, Olga V., Volovenko, Yulian M., Rybalchenko, Volodymyr K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458214/
https://ncbi.nlm.nih.gov/pubmed/31032168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40203-019-0051-2
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