Synthesis and biological activity of 4-amino-3-chloro-1H-pyrrole-2,5-diones

4-Amino-3-chloro-1H-pyrrole-2,5-dione derivatives were designed and synthesized as potential tyrosine kinase inhibitors. One of them has been shown to inhibit growth of cancer cell lines and in vivo tumors. To determine the impact of side groups on biological activity the ability of different 4-amin...

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Bibliografski detalji
Izdano u:In Silico Pharmacol
Glavni autori: Kuznietsova, Halyna M., Hurmach, Vasyl V., Bychko, Andriy V., Tykhoniuk, Olena I., Milokhov, Demyd S., Khilya, Olga V., Volovenko, Yulian M., Rybalchenko, Volodymyr K.
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2019
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458214/
https://ncbi.nlm.nih.gov/pubmed/31032168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40203-019-0051-2
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