GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA(A) receptor trafficking and social behavior

Dysfunctional mTOR signaling is associated with the pathogenesis of neurodevelopmental and neuropsychiatric disorders. However, it is unclear what molecular mechanisms and pathogenic mediators are involved and whether mTOR-regulated autophagy continues to be crucial beyond neurodevelopment. Here, we...

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Dettagli Bibliografici
Pubblicato in:Sci Adv
Autori principali: Hui, Kelvin K., Takashima, Noriko, Watanabe, Akiko, Chater, Thomas E., Matsukawa, Hiroshi, Nekooki-Machida, Yoko, Nilsson, Per, Endo, Ryo, Goda, Yukiko, Saido, Takaomi C., Yoshikawa, Takeo, Tanaka, Motomasa
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457945/
https://ncbi.nlm.nih.gov/pubmed/30989111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau8237
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