GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA(A) receptor trafficking and social behavior

Dysfunctional mTOR signaling is associated with the pathogenesis of neurodevelopmental and neuropsychiatric disorders. However, it is unclear what molecular mechanisms and pathogenic mediators are involved and whether mTOR-regulated autophagy continues to be crucial beyond neurodevelopment. Here, we...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Hui, Kelvin K., Takashima, Noriko, Watanabe, Akiko, Chater, Thomas E., Matsukawa, Hiroshi, Nekooki-Machida, Yoko, Nilsson, Per, Endo, Ryo, Goda, Yukiko, Saido, Takaomi C., Yoshikawa, Takeo, Tanaka, Motomasa
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457945/
https://ncbi.nlm.nih.gov/pubmed/30989111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau8237
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