GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA(A) receptor trafficking and social behavior

Dysfunctional mTOR signaling is associated with the pathogenesis of neurodevelopmental and neuropsychiatric disorders. However, it is unclear what molecular mechanisms and pathogenic mediators are involved and whether mTOR-regulated autophagy continues to be crucial beyond neurodevelopment. Here, we...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Hui, Kelvin K., Takashima, Noriko, Watanabe, Akiko, Chater, Thomas E., Matsukawa, Hiroshi, Nekooki-Machida, Yoko, Nilsson, Per, Endo, Ryo, Goda, Yukiko, Saido, Takaomi C., Yoshikawa, Takeo, Tanaka, Motomasa
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457945/
https://ncbi.nlm.nih.gov/pubmed/30989111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau8237
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