TDP-43 and DISC1 Co-Aggregation Disrupts Dendritic Local Translation and Mental Function in FTLD

BACKGROUND: Neurodegenerative diseases involving protein aggregation often accompany psychiatric symptoms. Frontotemporal lobar degeneration (FTLD) associated with TAR DNA-binding protein 43 kDa (TDP-43) aggregation is characterized by progressive neuronal atrophy in frontal and temporal lobes of ce...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biol Psychiatry
Prif Awduron: Endo, Ryo, Takashima, Noriko, Nekooki-Machida, Yoko, Komi, Yusuke, Hui, Kelvin Kai-Wan, Takao, Masaki, Akatsu, Hiroyasu, Murayama, Shigeo, Sawa, Akira, Tanaka, Motomasa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123275/
https://ncbi.nlm.nih.gov/pubmed/29752072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2018.03.008
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