TGF-β Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF-β Receptor Downregulation

BACKGROUND AND OBJECTIVES: Mesenchymal stem cells (MSCs) become hypertrophic in long term despite chondrogenic differentiation following the pathway of growth plate chondrocytes. This terminal differentiation leads to phenotypically unstable cartilage and was mirrored in vitro by addition of hypertr...

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Detalhes bibliográficos
Publicado no:Int J Stem Cells
Main Authors: Pfeifer, Christian G., Karl, Alexandra, Kerschbaum, Maximilian, Berner, Arne, Lang, Siegmund, Schupfner, Rupert, Koch, Matthias, Angele, Peter, Nerlich, Michael, Mueller, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Stem Cell Research 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457698/
https://ncbi.nlm.nih.gov/pubmed/30836731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15283/ijsc18088
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